University
Research and ideas from the people advancing bioprocessing.
We built Invert University to be at the center of the bioprocessing community and to advocate for the scientists doing the work. It is a place to share research, ideas, and hard-won lessons that move the field forward.
Closed-System Cell Washing and Concentration for MSCs
Beatriz Menéndez Yeves (Takeda) compares two closed-system technologies for this step across three bioreactor runs of mesenchymal stromal cells (MSCs). The CTS Rotea counterflow centrifuge (Thermo Fisher) recovered ~92% of cells, concentrated them roughly fourfold, and removed dead cells through elutriation, making it well suited to cryopreservation and dose preparation. The Unifuge Mini (CARR Biosystems), a tubular-bowl centrifuge, matched ~90% recovery while processing larger volumes faster, making it better suited to high-throughput manufacturing. For MSAT, PD, and cell therapy manufacturing teams choosing between closed-system concentration technologies.
The library
18:50Automated Water-Free Thawing Device
Raúl Valero Carabias · Takeda / Universidad de Extremadura
Read the paper